Aplicaciones Clínicas de la Membrana Amniótica Humana

“La búsqueda de alternativas terapéuticas que permiten reemplazar los tejidos u órganos dió como resultado la utilización de células y tejidos con fines terapéuticos”.

El Dr. Sebastián San Martín Henríquez, quien labora en el Centro de Investigaciones Biomédicas de la Escuela de Medicina, en la Facultad de Medicina de la Universidad de Valparaíso, Chile, participó con una ponencia durante el “XX Congreso de la Sociedad Española de Histología e Ingeniería Tisular VIII International Congress of Histology and Tissue Engineering VI Congreso Iberoamericano de Histología” (SEHIT 2019), los días 04 y 06 de septiembre en la ciudad de Murcia, España. https://www.um.es/sehit19/es/index.php

El tema presentado por el Dr. San Martín, trató sobre la “Membrana amniótica humana: de la investigación básica a las aplicaciones clínicas”, ponencia de gran interés para nuestros lectores, motivo por el cual, InvestingMedic conversó con este renombrado investigador para obtener un breve resumen de lo expuesto.

..” La Membrana amniótica humana: de la investigación básica a las aplicaciones clínicas”, ponencia presentada en el SEHIT 2019.

Existen una serie de condiciones patológicas que dañan la estructura de órganos y tejidos del cuerpo humano y por ende su normal funcionamiento. La búsqueda de alternativas terapéuticas que permiten reemplazar los tejidos u órganos ha dado las bases para la utilización de células y tejidos con fines terapéuticos. En este sentido, la membrana amniótica (MA) humana es una alternativa concreta que dada sus propiedades biológicas permite la recuperación de tejidos dañados producto de algún traumatismo o enfermedad.

La MA, es una membrana delgada que recubre al embrión y feto durante toda la gestación. Se forma tempranamente durante el desarrollo a partir de la capa epiblástica del embrión. Posee una capa de células epiteliales y un estroma en el cual se encuentran inmersas células mesenquimáticas. Ambos tipos celulares poseen características típicas de célula madre, además de poseer en la matriz extracelular del amnios una serie de proteínas con acciones antiinflamatorias, analgésicas, antifibróticas y regenerativas, entre otras.

En nuestro grupo y dado el trabajo colaborativo con diferentes especialistas clínicos hemos usado la membrana amniótica en el área oftalmológica, en el tratamiento de quemaduras de la superficie cutánea, así como en modelos experimentales que ha permitido corroborar las propiedades terapéuticas mencionadas previamente.

…Hablemos de la Medicina de Precisión y sus aportes a la Histología.

En los últimos años, cada vez más es necesario generar alternativas terapéuticas que respondan a las necesidades del paciente en particular, como de los propios sistemas sanitarios desde el punto de vista de mayor efectividad y bajo costo. En este sentido, la utilización de la MA surge como una alternativa de tratamiento para una serie de condiciones en los cuales sea necesario recuperar la estructura normal de los tejidos y su funcionalidad.

Este tejido considerado como un producto de desecho posterior al parto, tiene una serie de propiedades biológicas que han sido documentadas desde hace más de 100 años. Existen algo más de 100 ensayos clínicos en donde la MA se ha utilizado con fines terapéuticos en diferentes áreas.

Es así que es posible utilizar la MA de acuerdo a las condiciones o enfermedad que posee el paciente en particular y buscar en ese sentido y de acuerdo a las características de la MA su mejor funcionalidad para obtener la mejor respuesta y así promover la recuperación del tejido y por lo tanto la salud del individuo.

Para determinar las propiedades biológicas de la MA es necesario la realización de estudios que permitan conocer la estructura de la MA, los factores o proteínas que conforman este tejido y al mismo tiempo como producto de su uso es posible generar la recuperación de los tejidos dañados.

Es así que la histología ofrece un enorme potencial para describir como la MA ejerce sus efectos en los tejidos, conocer la relación espacial de la relación membrana-tejido y como éste último responde desde el punto de vista morfológico al efecto terapéutico de la membrana.

…Algunas Estrategias que se implementan para difundir el desempeño y los resultados obtenidos en los proyectos de investigación

La difusión de los resultados de nuestra investigación se hace mediante publicaciones de artículos científicos en revistas de corriente principal, presentaciones en Congresos, por ejemplo: el XX Congreso de la Sociedad Española de Histología e Ingeniería Tisular – VIII International Congress of Histology and Tissue Engineering VI Congreso Iberoamericano de Histología, celebrado recientemente en la ciudad de Murcia, España.

Al mismo tiempo en nuestro país, hemos realizado presentaciones en los Servicios de Salud, Hospitales y reuniones clínicas para incentivar el uso de la MA como agente beneficioso en la terapia tisular.

InvestingMedic agradece la colaboración del Dr. Sebastián San Martín Henríquez, por contribuir en la promoción y difusión del conocimiento médico, académico y científico, que forman parte de la Medicina de Precisión, con una visión sistémica y participativa.

Artículos de Interés:

Transplantation of Human Amniotic Membrane over the Liver Surface Reduces Hepatic Fibrosis in a Cholestatic Model in Young Rats. Garrido M, Escobar C, Zamora C, Rejas C, Varas J, Córdova C, Papuzinski C, Párraga M, San Martín S, Montedonico S.Stem Cells Int. 2018 Feb 25;2018:6169546. doi: 10.1155/2018/6169546. eCollection 2018.

Comparative Analysis of Human Amniotic Membrane Graft versus Contact Lenses in Symptomatic Bullous Keratopathy Venegas L1, Hettich M , Villena J, Aris R , Párraga M , Parolini O , Alaminos M, Campos A and San Martin S J Stem Cell Res Ther 2014, 4:11 DOI: 10.4172/2157-7633.1000250

Enlaces de Interés:

  1. Organización Nacional de Trasplantes. Madrid, España: Información Ciudadano: Donación de Tejidos. Recuperado de: http://www.ont.es/informacion/Paginas/Donaci%c3%b3ndeTejidos.aspx
  2. Organización Nacional de Trasplantes. Madrid, España: Información Especializada: Tejidos, PH y Células. Recuperado de: http://www.ont.es/infesp/Paginas/Tejidos,PHyCelulas.aspx
  3. Unidad de Terapia Celular y Trasplante Hematopoyético. Instituto Murciano de Investigación Biosanitaria (IMIB-Virgen de la Arrixaca). Departamento de Medicina Interna. Universidad de Murcia. http://www.imib.es/portal/index.jsf
  4. Departamento de Histología. Facultad de Medicina. Universidad de Granada. https://histologiaugr.es/grupo-de-investigacion-en-ingenieria-tisular/
  5. XX CONGRESO DE LA SOCIEDAD ESPAÑOLA DE HISTOLOGÍA E INGENIERÍA TISULAR/ VIII INTERNATIONAL CONGRESS OF HISTOLOGY AND TISSUE ENGINEERING VI CONGRESO IBEROAMERICANO DE HISTOLOGÍA. 2019. https://www.um.es/sehit19/es/index.php
  6. Instituto de Salud Carlos III. Madrid, España: Comités de Ética. Recuperado de: https://www.isciii.es/QueHacemos/Servicios/ComitesEtica/Paginas/default.aspx

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